1. a radical change, a dramatic change
to bring about a paradigm shift
A paradigm shift is an expression usually associated with scientific discoveries and refers to complete change in understanding or an approach to any discipline. Usually, this is as a result of new research which changes fundamental knowledge of how something works or came to be. "Widespread access to the internet has lead to a paradigm shift in how we conduct any kind of business."
Darwin's theory of evolution brought about a paradigm shift in the way we think about natural science.
The Invention of the Gene CRISPR has brought about a paradigm shift in genetic engineering.