The expression 'no matter' is another way of saying regardless of. If you say you are going to do something 'no matter what', it means you intend to do something despite obstacles, challenges or difficulties. When you use the phrase 'no matter what' it means you intend to do something. 

1. No matter what happens, I promise that I will make it to your concert tonight.
2. You are one of the smartest students in the class, no matter what anyone else says.
3. No matter what I do, I can't seem to get the television to work.

1. We need to get three more big clients by years end no matter what.
2. No matter what I am going to exceed my quotas this quarter. I am determined not to let me track record slip.