1. attempt to accomplish, solve, or achieve something
take a run at fixing a problem
When you 'take a run at something' or 'make a run at something', you attempt to do something or complete something challenging or when you don't have too much previous experience or knowledge about something. Similar in meaning to 'take a stab at something' or 'to give it a go'. This is a casual expression but you can use it in informal social and professional contexts.