1. release or give (something) up
let go of your anger, let go from job
To 'let something go' can mean to physically release it or to let it free. "He was finally able to let the pain from his terrible childhood go." "If you let that rabbit go it will escape in seconds." It can also mean to dismiss something or chose not to react to it. "I am going to let that comment go and assume that you didn't express yourself very well." "He made some unsavoury remarks but I let them go this time." It can also mean to dismiss someone from work or a job. "The pharmaceutical company let twelve people go from their headquarters in the city earlier today."