completely destroy or remove something
extirpate - destroy
The best way to understand how to use this word is to think of something unpleasant and unwanted like a weed. To remove that you could cut it, but it would just grow again. To 'extirpate' it, you would need to pull it up by its roots. In that way you remove it permanently.
The issue has never really gone away, despite our repeated attempts to extirpate it.
That country’s new government has been conducting the extirpation of all the changes made by the former regime.
The patient will need to undergo a bladder removal, which is a major extirpative surgical procedure.